![]() ![]() ![]() Loss of the mitochondrial iron-sulfur cluster (ISC) assembly system in some organisms in this group appears to be linked to the acquisition in their common ancestral lineage of a SUF-like minimal system (SMS) Fe/S cluster pathway through lateral gene transfer (LGT). Extensive bioinformatic analyses of the manually curated gene models showed that these organisms have extremely reduced MROs in comparison to other free-living metamonads. Phylogenomic analyses place these organisms in a clade sister to the Fornicata – a group of metamonads that includes parasitic and free-living diplomonads and Carpediemonas-like organisms. To further investigate metamonad MRO diversity, we generated high quality draft genomes, transcriptomes, and predicted proteomes for five recently discovered free-living metamonads. ![]() All metamonads but one harbour metabolically altered ‘mitochondrion-related organelles’ (MROs) with reduced functions relative to aerobic mitochondria, however the degree of reduction varies markedly over the metamonad tree. Metamonads are a diverse group of heterotrophic microbial eukaryotes adapted to living in hypoxic environments. ![]()
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